Placental Mitochondrial Function and Dysfunction in Preeclampsia.

Key Findings: evidence of placental mitochondrial dysfunction in the context of preeclampsia (PE) highlights how altered mitochondrial function may be a common feature across distinct PE subtypes.

Jahan F*, Vasam G*, Green AE*, Bainbridge SA, Menzies KJ.

Int J Mol Sci. 2023 Feb 20;24(4):4177. doi: 10.3390/ijms24044177.

PMID: 36835587; PMCID: PMC9963167.

Association of distinct features of villitis of unknown etiology histopathology and intrauterine growth restriction diagnosis in a retrospective cohort from Eastern Ontario.

Key findings: location of villitis may be associated with worse neonatal outcomes.

Osborne B, Oltean I, Sucha E, Mitsakakis N, Barrowman N, Bainbridge S, El Demellawy D.

Placenta. 2022 Oct;128:83-90. doi: 10.1016/j.placenta.2022.08.012. Epub 2022 Aug 30.

PMID: 36099701.

Maternal immune cell and cytokine profiles to predict cardiovascular risk profiles 6-months after pre-eclampsia

Key findings: subtle differences in immune cell profiles may help distinguish individuals at low and high cardiovascular disease risk in the early postpartum period and warrants further investigation.

Murphy M, Benton SJ*, Cox B, Nerenberg K, McComb S, Krishnan L, Weeratna RD, Pare JF, Dingwall-Harvey ALJ, Bainbridge SA, Gruslin A, Gaudet LM.

J Clin Med. 2022 Jul 19;11(14):4185. doi: 10.3390/jcm11144185.

PMID: 35887949; PMCID: PMC9317739.

Automatic Placental Distal Villous Hypoplasia Scoring using a Deep Convolutional Neural Network Regression Model

Key findings: deep learning approach is a promising approach for automated analysis of placental histopathology images.

Khodaee A, Grynspan D, Bainbridge SA, Ukwatta E, Chan ADC.

IEEE International Instrumentation and Measurement Technology. 2022.

doi: 10.1109/I2MTC48687.2022.9806589.

Placental Pathology as a Tool to Identify Women for Postpartum Cardiovascular Risk Screening Following Preeclampsia: A Preliminary Investigation.

Key findings: placenta pathology may provide a unique modality to identify women for cardiovascular screening.

Benton SJ, Mery EE, Grynspan D, Gaudet LM, Smith GN, Bainbridge SA.

J Clin Med. 2022 Mar 13;11(6):1576. doi: 10.3390/jcm11061576.

PMID: 35329905; PMCID: PMC8954716.

Metabolomics to understand placental biology: Where are we now?

Key findings: discuss the technical aspects of metabolomics and review the current literature describing the placental metabolome in human and animal models, in the context of health and disease.

Mohammad S, Bhattacharjee J, Vasanthan T, Harris CS, Bainbridge SA, Adamo KB.

Tissue Cell. 2021 Dec;73:101663. doi: 10.1016/j.tice.2021.101663. Epub 2021 Oct 6.

PMID: 34653888.

Placental morphology and the prediction of underlying cardiovascular risk factors.

Key findings: identify clinical measurements that can be collected at the time of delivery which may help identify specific women who may benefit most from postpartum cardiovascular risk screening and intervention.

Zaza A, Pudwell J, Bainbridge S, Connor K, Smith GN.

Eur J Obstet Gynecol Reprod Biol. 2021 Aug;263:56-61. doi: 10.1016/j.ejogrb.2021.05.046. Epub 2021 Jun 6.

PMID: 34167034.

Histopathology findings in pregnancies with placental disease according to recipient versus donor oocyte derivation for in vitro fertilization.

Key findings: multiple gestation may be associated with decreased MVM and total lesions.

Dancey S, Mery E, Esteves A, Oltean I, Hayawi L, Tang K, Bainbridge S, El Demellawy D.

Placenta. 2021 May;108:114-121. doi: 10.1016/j.placenta.2021.03.012. Epub 2021 Mar 23.

PMID: 33865182.

Maternal and cord blood metabolite associations with gestational weight gain and pregnancy health outcomes

Key findings: metabolic biomarkers predictive of gestational weight gain could aid in the guidance of prenatal weight management plans as the majority of pregnancy weight gain occurs in the third trimester.

Shearer J, Klein MS, Vogel HJ, Mohammad S, Bainbridge S, Adamo KB.

J Proteome Res. 2021 Mar 5;20(3):1630-1638. doi: 10.1021/acs.jproteome.0c00854. Epub 2021 Feb 2.

PMID: 33529033.

Fibrinogen-Like Protein 2-Associated Transcriptional and Histopathological Features of Immunological Preeclampsia. Hypertension

Key findings: FGL-2 expression levels reflect the unique pathophysiology that leads to immunological preeclampsia, leading to its potential as a subtype-specific biomarker.

Robineau-Charette P, Grynspan D, Benton SJ, Gaudet J, Cox BJ, Vanderhyden BC, Bainbridge SA.

Hypertension. 2020 Sep;76(3):910-921. doi: 10.1161/HYPERTENSIONAHA.120.14807. Epub 2020 Jul 27.

PMID: 32713274; PMCID: PMC7418930.

Automated segmentation of villi in histopathology images of placenta

Key findings: compared to existing methods, our developed method yielded high accuracy in detecting villi in placental images.

Salsabili S, Mukherjee A, Ukwatta E, Chan ADC, Bainbridge S, Grynspan D.

Comput Biol Med. 2019 Oct;113:103420. doi: 10.1016/j.compbiomed.2019.103420. Epub 2019 Aug 30.

PMID: 31514041.

A synoptic framework and future directions for placental pathology reporting

Key findings: propose a synoptic reporting framework for placental pathology based on current consensus guidelines.

Benton SJ, Lafreniere AJ, Grynspan D, Bainbridge SA.

Placenta. 2019 Feb;77:46-57. doi: 10.1016/j.placenta.2019.01.009. Epub 2019 Jan 11. Review.

PMID:30827355

Placental transcriptional and histologic subtypes of normotensive fetal growth restriction are comparable to preeclampsia

Key findings: provides evidence for at least 2 pathologic placental causes of normotensive small-for-gestational-age, likely representing true fetal growth restriction.

Gibbs I, Leavey K, Benton SJ, Grynspan D, Bainbridge SA, Cox BJ.

Am J Obstet Gynecol. 2019 Jan;220(1):110.e1-110.e21. doi: 10.1016/j.ajog.2018.10.003. Epub 2018 Oct 9.

PMID:30312585

The clinical heterogeneity of preeclampsia is related to both placental gene expression and placental histopathology

Benton SJ, Leavey K, Grynspan D, Cox BJ, Bainbridge SA.

Am J Obstet Gynecol. 2018 Dec;219(6):604.e1-604.e25. doi: 10.1016/j.ajog.2018.09.036. Epub 2018 Sep 29.

PMID:30278173

A crucial role for maternal dietary methyl donor intake in epigenetic programming and fetal growth outcomes 

McGee, M., Bainbridge, S., & Fontaine-Bisson, B.

Nutrition reviews, 76(6), 469-478. doi: 10.1093/nutrit/nuy006 Epub 2018 June 1

PMID: 29529267

Vaccinium angustifolium (lowbush blueberry) leaf extract increases extravillous trophoblast cell migration and invasion in vitro.

Ly, C., Ferrier, J., Gaudet, J., Yockell‐Lelièvre, J., Arnason, J., Gruslin, A., Bainbridge, S.

Phytotherapy Research 32.4 (2018): 705-714. doi: 10.1002/ptr.6021. Epub 2018 Jan 29.

PMID: 29377302

Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia

Leavey K, Wilson SL, Bainbridge SA, Robinson WP, Cox BJ.

Clin Epigenetics. 2018 Mar 2;10:28. doi: 10.1186/s13148-018-0463-6. eCollection 2018.

PMID: 29507646

Gene markers of normal villous maturation and their expression in placentas with maturational pathology.

Leavey K, Benton SJ, Grynspan D, Bainbridge SA, Morgen EK, Cox BJ.

Placenta. 2017 Oct;58:52-59. doi: 10.1016/j.placenta.2017.08.005. Epub 2017 Aug 12.

PMID: 28962696

A role for maternally derived myokines to optimize placental function and fetal growth across gestation.

Dubé C, Aguer C, Adamo K, Bainbridge S.

Appl Physiol Nutr Metab. 2017 May;42(5):459-469. doi: 10.1139/apnm-2016-0446. Epub 2017 Jan 17.

PMID: 28177716

Andrée Gruslin award lecture: Metabolomics as an important modality to better understand preeclampsia.

Benton SJ, Ly C, Vukovic S, Bainbridge SA.

Placenta. 2016 Nov 16. pii: S0143-4004(16)30626-9. doi: 10.1016/j.placenta.2016.11.006. [Epub ahead of print]

PMID: 27889063

Unsupervised Placental Gene Expression Profiling Identifies Clinically Relevant Subclasses of Human Preeclampsia.

Leavey K, Benton SJ, Grynspan D, Kingdom JC, Bainbridge SA, Cox BJ.

Hypertension. 2016;

PubMed [journal]   PMID: 2716020

Oocyte donation pregnancies and the risk of preeclampsia or gestational hypertension: a systematic review and metaanalysis.

Masoudian P, Nasr A, de Nanassy J, Fung-Kee-Fung K, Bainbridge SA, El Demellawy D.

American journal of obstetrics and gynecology. 2016; 214(3):328-39

PubMed [journal]   PMID: 26627731

Effect of folic acid on human trophoblast health and function in vitro.

Ahmed T, Fellus I, Gaudet J, MacFarlane AJ, Fontaine-Bisson B, Bainbridge SA.

Placenta. 2016; 37:7-15.

PubMed [journal]   PMID: 26748157

IFPA meeting 2015 workshop report: Mechanistic role of the placenta in fetal programming; biomarkers of placental function and complications of pregnancy; late onset fetal growth restriction surveillance and monitoring.

Andraweera PH, Bobek G, Bowen C, Burton GJ, Correa Frigerio P, Chaparro A, Dickinson H, Duncombe G, Hyett J, Illanes SE, Johnstone E, Kumar S, Morgan TK, Myers J, Orefice R, Roberts CT, Salafia CM, Thornburg KL, Whitehead CL, Bainbridge SA.

Placenta. 2015;

PubMed [journal]   PMID: 26733365

Large scale aggregate microarray analysis reveals three distinct molecular subclasses of human preeclampsia.

Leavey K, Bainbridge SA, Cox BJ.

PloS one. 2015; 10(2):e0116508.

PubMed [journal]   PMID: 25679511   PMCID: PMC4332506

IFPA Meeting 2013 Workshop Report I: diabetes in pregnancy, maternal dyslipidemia in pregnancy, oxygen in placental development, stem cells and pregnancy pathology.

Abumaree MH, Alahari S, Albrecht C, Aye IL, Bainbridge S, Chauvin S, Clifton VL, Desoye G, Ermini L, Giuffrida D, Graham CH, Huang QT, Kalionis B, Lager S, Leach L, Li Y, Litvack ML, Nuzzo AM, Moretto-Zita M, O'Tierney-Ginn P, Powell T, Rolfo A, Salomon C, Serov A, Westwood M, Yung HW, Lash GE.

Placenta. 2014; 35 Suppl:S4-9.

PubMed [journal]   PMID: 24321782

Endothelial NO synthase augments fetoplacental blood flow, placental vascularization, and fetal growth in mice.

Kulandavelu S, Whiteley KJ, Bainbridge SA, Qu D, Adamson SL.

Hypertension. 2013; 61(1):259-66.

PubMed [journal]   PMID: 23150513

Significance of IGFBP-4 in the development of fetal growth restriction.

Qiu Q, Bell M, Lu X, Yan X, Rodger M, Walker M, Wen SW, Bainbridge S, Wang H, Gruslin A.

The Journal of clinical endocrinology and metabolism. 2012; 97(8):E1429-39.

PubMed [journal]   PMID: 22689691

Endothelial nitric oxide synthase deficiency reduces uterine blood flow, spiral artery elongation, and placental oxygenation in pregnant mice.

Kulandavelu S, Whiteley KJ, Qu D, Mu J, Bainbridge SA, Adamson SL.

Hypertension. 2012; 60(1):231-8.

PubMed [journal]   PMID: 22615111

Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.

Bainbridge SA, Minhas A, Whiteley KJ, Qu D, Sled JG, Kingdom JC, Adamson SL.

Hypertension. 2012; 59(3):732-9.

PubMed [journal]   PMID: 22275534

Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers.

Bainbridge SA, Roberts JM, von Versen-Höynck F, Koch J, Edmunds L, Hubel CA.

American journal of physiology. Cell physiology. 2009; 297(2):C440-50.

PubMed [journal]   PMID: 19535510   PMCID: PMC2724097

Increased xanthine oxidase in the skin of preeclamptic women.

Bainbridge SA, Deng JS, Roberts JM.

Reproductive sciences (Thousand Oaks, Calif.). 2009; 16(5):468-78. NIHMSID: NIHMS251714

PubMed [journal]   PMID: 19196876   PMCID: PMC2992872

Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor.

von Versen-Höynck F, Rajakumar A, Bainbridge SA, Gallaher MJ, Roberts JM, Powers RW.

Placenta. 2009; 30(5):434-42. NIHMSID: NIHMS100410

PubMed [journal]   PMID: 19303140   PMCID: PMC2674514

Uric acid inhibits placental system A amino acid uptake.

Bainbridge SA, von Versen-Höynck F, Roberts JM.

Placenta. 2009; 30(2):195-200. NIHMSID: NIHMS107438

PubMed [journal]   PMID: 19058847   PMCID: PMC2677697

Uric acid as a pathogenic factor in preeclampsia.

Bainbridge SA, Roberts JM.

Placenta. 2008; 29 Suppl A:S67-72. NIHMSID: NIHMS45160

PubMed [journal]   PMID: 18093648   PMCID: PMC3319018

Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy.

Magee LA, Helewa M, Moutquin JM, von Dadelszen P.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC. 2008; 30(3 Suppl):S1-48.

PubMed [journal]   PMID: 18817592

Glyceryl trinitrate inhibits hypoxia/reoxygenation-induced apoptosis in the syncytiotrophoblast of the human placenta: therapeutic implications for preeclampsia.

Belkacemi L, Bainbridge SA, Dickinson MA, Smith GN, Graham CH.

The American journal of pathology. 2007; 170(3):909-20.

PubMed [journal]   PMID: 17322376   PMCID: PMC1864864

Carbon monoxide inhibits hypoxia/reoxygenation-induced apoptosis and secondary necrosis in syncytiotrophoblast.

Bainbridge SA, Belkacemi L, Dickinson M, Graham CH, Smith GN.

The American journal of pathology. 2006; 169(3):774-83.

PubMed [journal]   PMID: 16936254   PMCID: PMC1698837

The effect of nicotine on in vitro placental perfusion pressure.

Bainbridge SA, Smith GN.

Canadian journal of physiology and pharmacology. 2006; 84(8-9):953-7.

PubMed [journal]   PMID: 17111041

HO in pregnancy.

Bainbridge SA, Smith GN.

Free radical biology & medicine. 2005; 38(8):979-88.

PubMed [journal]   PMID:15780756

Direct placental effects of cigarette smoke protect women from pre-eclampsia: the specific roles of carbon monoxide and antioxidant systems in the placenta.

Bainbridge SA, Sidle EH, Smith GN.

Medical hypotheses. 2005; 64(1):17-27.

PubMed [journal]   PMID: 15533604

Carbon monoxide decreases perfusion pressure in isolated human placenta.

Bainbridge SA, Farley AE, McLaughlin BE, Graham CH, Marks GS, Nakatsu K, Brien JF, Smith GN.

Placenta. 2002; 23(8-9):563-9.

PubMed [journal]   PMID: 12361675